Suicidality in individuals with Prader-Willi syndrome: a review of registry survey data

Abstract Introduction Prader–Willi syndrome (PWS) is a rare, genetic, neurodevelopmental associated with hyperphagia and early onset obesity, growth sex hormone insufficiencies, mild-to-moderate intellectual disability, behavioral challenges such as compulsivity, anxiety, skin picking, social skills deficits temper outbursts. Given high rates of psychiatric comorbidity potential risk factors for suicide in PWS, this study sought first estimate the prevalence suicidal ideation (SI) attempts (SA) PWS population any characteristics suicidality population. Methods Using Global Prader-Willi Syndrome Registry, we included all participants who had answered question about SI. We examined most recent data from surveys social, economic, demographic factors, genetic subtype, symptoms treatments. A chi-square analysis was used to compare registry reported SI those without Results From 750 survey respondents, 94 (12.5%) endorsed some history Of these, 25 (26.6%) also SA, an average age 16.25 years at their attempt. Those were predominantly male adult age, higher aggression comorbidities, therapies, medications. Conclusions This indicates that rate SA comparable general population, typically begin middle-teenage years. Despite unique challenges, individuals caregivers should be screens psychoeducation mental health concerns.